The world of ethics and moral understanding of medicine was turned upside down as human rights were ignored in the attempt to understand the anatomy of the human body, as well as its various responses to different drugs and environments. Human experimentation and subject research were of little interest to society before the 20th century (“Human Experimentation, Plutonium, and Colonel Stafford Warren”). The onset of the Holocaust increased the popularity of that medical field. Experimentation on human subjects has changed dramatically from the 20th to the 21st century with regards to consent and subject status, the intent of the experiments, and the laws and policies passed. In 1900, Walter Reed, a 49-year-old doctor, conducted medical experiments on subjects who voluntarily consented to the tests. One of his experiments involved his medical staff at the US Army Yellow Fever Commission being bitten by mosquitoes carrying yellow fever ("A Slap in the Face of Major Walter Reed"). The goal was not chaotic, but specific to finding a cure. In the 1940s, however, at the onset of the Holocaust, dangerous experiments intended to test human boundaries were performed without the subjects' consent and in unsafe environments. These vicious experiments were imposed on Jewish prisoners by two Nazi doctors, Josef Mengele and Shiro Ishii ("Human Experimentation, Plutonium, and Colonel Stafford Warren"). The condition of the subjects was dirty and brutal, in appearance and treatment. Many of the experiments left victims maimed and psychologically scarred. They consisted of disease injections, exposure to various poisons, and exposure to extreme temperatures. Later in 1946, Germany received a slap on… middle of paper… Net Industries, 2011. Web..3. “Human Experimentation, Plutonium, and Colonel Stafford Warren.” Burton Report. XI. 2000. Web..4. “Medical Research and Human Subjects.” Burton Report. XI. 2000. Network. .5. “Nuremberg Code”. Wikipedia. Wikimedia Foundation Inc., 2001. Web.6. Sanford, Christie. "Laboratory Science". Use of human subjects for medical research. Np, 1997. Web. 30 April 2011..7. Standler, Ronald. “Non-consensual medical experiments on humans. “ Ronald B. Standler, June 18, 2000. Web. April 30 2011. .